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KMID : 0377619970620090774
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Korean Jungang Medical Journal
1997 Volume.62 No. 9 p.774 ~ p.774
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Effect of epidermal growth factor on the production of cortisol, thyroxine, and prolactin in fetal rabbits
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Kim, Yong Wook
Lee, Jong Kun/Baik, Eun Jeoug/Yi, Chong Seong/Kim, Sa Jin/Rha, Jong Gu/Kim, Soo Pyung
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Abstract
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Respiratory distress syndrome(RDS) is a major cause of death in premature neonates, and caused by the failure of morphologic and biochemical lung maturation (synthesis and secretion of lung surfactant). It is known that cortisol, thyroxine, prolactin, epidermal growth factor(EGF), and estrogen accelerate the lung maturation. Cortisol and thyroxine are currently used in the antenatal treatment for the prevention of RDS in premature neonates.
In order to evaluate the effect of EGF on the in vivo levels of cortisol, thyroxine, and prolactin, this study was undertaken. Phosphate buffered saline(PBS) with or without EGF was directly injected into the 25 days´ gestational fetus in uterus. One and two days after the injection, the blood was collected for the measurement of cortisol, thyroxine, and prolactin. Body weights and lung weights were also measured.
The results were as follows:
1. There was no significant difference in body weights and lung weights between PBS-treated group(control group) and EGF-treated group (experimental group), 24 hours and 48 hours after the injection.
2. The levels of cortisol were significantly increased in the EGF-treated group 24 hours after injection compared with those in PBS-treated group, but there was no significant difference in the levels of cortisol between two groups, 48 hours after injection.
The levels of thyroxine and prolactin in EGF-treated group did not significantly differ from those in PBS-treated group, 24 hours and 48 hours after the injection.
In conclusion, the in vivo synthesis of cortisol may be affected by EGF treatment. It suggests that the action of EGF may be partially mediated by the increased endogenous levels of cortisol.
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